As part of Iona Presentation College's commitment to STEM focus (Science, Technology, Engineering and Mathematics), students are supported in their development of skills in cross-disciplinary, critical and creative thinking, problem-solving and digital technologies, which are essential in all 21st century occupations.

Iona Presentation College students across all year levels are engaging in learning programs and activities aimed to increase their interest in STEM-related fields, whilst improving problem-solving and critical analysis skills, giving students the foundations which enable them to engage with, and succeed in, the world beyond the school gate.

Within the curriculum, Iona girls engage in all areas of STEM. For Years 9 and 10 girls, Challenge Science offers opportunity to study many facets of the Science curriculum, not otherwise covered comprehensively in the core Science classes. In these classes the girls engage in; construction and programming of drones, and apps for smartphones; engineering studies leading to 3D printing and Engineering and Astronomy mentoring through programs with WA universities. Epigenetics is a new branch of genetics that the girls are also studying.

The Year 8 elective, ILSA (INSPIRE-LEARN-SUCCEED-ACHIEVE ), provides the girls with experience with 3D Computer Aided Design (CAD), animation technologies and the study and application of nanotechnology. Social Physics, a relatively new branch of science, will become part of this course in 2018.